A team of Miami-Dade Police Department forensic scientists investigate the circumstances behind unusual deaths and crimes. Lieutenant Horatio Caine (David Caruso) leads the CSI team and is a forensic analyst and former bomb squad officer. Members of his team include ballistics specialist Calleigh Duquesne (Emily Procter), fingerprint and drug identification expert Eric Delko (Adam Rodriguez), medical examiner Dr. Alexx Woods (Khandi Alexander), young officer Ryan Wolfe (Jonathan Togo), Homicide Detective Frank Tripp (Rex Linn), and DNA analyst Natalia Boa Vista (Eva LaRue).