In the small New England town of Eastwick, three women make wishes at a fountain and become fast friends. Soon afterward, a very wealthy and mysterious man named Darryl Van Horne (Paul Gross) moves to the area and befriends the three women.

The ladies have a hard time resisting his wealth, charisma, and bad boy sex appeal. Darryl unleashes supernatural powers from within them, igniting their hearts’ desires, and opening more of a Pandora’s Box than even he could have expected.

Roxie Torcoletti (Rebecca Romijn) is an artistic free-spirited widow who lives by her own rules. Living with her teenage daughter, Mia (Ashley Benson), Roxie has a much younger boyfriend and persistent money problems. All of this doesn’t exactly endear her to her neighbors. Things start to change however when Darryl unleashes her power to see into the future.

Joanna Frankel (Lindsay Price) is a newspaper reporter for the Eastwick Gazette who’s also very shy and awkward. Darryl helps her get over these problems by telling her that she just needs to look people in the eye and tell them what she wants. It works and she even lands a guy she’s fancied for a long time, Gazette photographer Will St. David (Johann Urb).

Kat Gardener (Jaime Ray Newman) is the mother of five and is married to her high school sweetheart, beer-loving Raymond (Jon Bernthal). A registered nurse and the breadwinner of the house, she wishes dearly for a change in her life. Kat finds that she has healing abilities and an amazing green thumb. Things start to get out of hand when she unintentionally targets her lazy, unemployed husband.