This drama focuses on a group of medical interns, residents and doctors working at the fictional Seattle Grace Hospital in Seattle, Washington. The story begins with Meredith Grey (Ellen Pompeo), Cristina Yang (Sandra Oh), Isobel “Izzie” Stevens (Katherine Heigl), Alex Karev (Justin Chambers), and George O’Malley (T.R. Knight) at the start of their time as interns.