Dr. Richard Kimble (David Janssen), a pediatrician in Stafford, Indiana, is wrongly convicted of murdering his wife Helen (Diane Brewster) and sentenced to the death penalty.

Prior to Helen’s death, it was no secret in their small town that the Kimbles were having marital trouble. On the night of the crime, they argued loudly and were overheard by their neighbors. To calm down after the fight with Helen, Kimble left his house and went for a drive. Upon his return, he saw a one-armed man leaving and found his wife had been murdered. But no one had seen Kimble go on his drive and he’s subsequently arrested and convicted of the deed.

En route to death row, Kimble’s train derails and crashes, allowing him to escape. Now more determined than ever to solve the case on his own, he travels from town to town while tracking the killer. He’s also evading Lt. Philip Gerard (Barry Morse), who is as obsessed in finding Kimble as Kimble is of finding one-armed man, Fred Johnson (Bill Raish).

Kimble changes his appearance, takes on aliases, and works low-paying, anonymous jobs in order to continue traveling and dodging the police. This drama follows Kimble in his pursuit for the truth and proves there’s no rest for the wicked… or the innocent.