This drama revolves around the students of Cyprus-Rhodes University who follow the school's Greek system. Much of the show takes place within the school's Kappa Tau Gamma or Omega Chi Delta fraternities, or the Omega Chi Delta sorority.
Casey Cartwright (Spencer Grammer) is a member of the Zeta Beta Zeta house, the number one sorority on campus. She's one half of the CRU's power couple and feels she's destined for greatness. When her little brother Rusty (Jacob Zachar) pledges Greek, Kappa Tau Gamma, she helps him out where she can. Rusty is Casey's social opposite, but rushes Greek in order to get rid of that nerdy image. He becomes a busy guy keeping up with his honors classes as well as his pledge duties.
"Cappie" (Scott Michael Foster) is only known by his nickname around school, as his given name is too embarrassing. He's also known as "Rob Thomas Guy" because of his resemblance to the singer. He's the president of the Kappa Tau Gamma fraternity, the black sheep fraternity at CRU, and at one time dated Casey, who he's still in love with.
Evan Chambers (Jake McDorman) is the President of Omega Chi Delta, the number one fraternity on campus. He and Cappie used to be best friends, until they pledged different fraternities and Evan started dating Casey.
Calvin Owens (Paul James) is a Greek legacy because of his father's involvement. He seems like a typical good-looking, intelligent frat guy but is secretly gay.
Ashleigh Howard (Amber Stevens) is the President of the Zeta Beta Zeta, and a bright, bubbly girl. She won the position in an un-nominated bid because of her strong sense of conviction and sunny disposition. Rebecca Logan (Dilshad Vadsaria) is another member of the Zeta Beta Zeta and a senator's daughter. She uses that to get herself and others out of trouble.
Frannie Morgan (Tiffany Dupont) is the former President of Zeta Beta Zeta, who was forced to step down from her position because of a scandal. She tried to open a new sorority, but that didn't last. She dates Evan to help her ailing social status.
Dale Kettlewell (Clark Duke) is Rusty's roommate, but chooses to not pledge Greek, being afraid of the consequences of that life. He instead starts up the U-SAG (University Students Against Greeks), striving for moral sanity and social equality. Highly religious, he has pledged chastity and is known for sticking by his "Purity Pledge Brothers" at all times.