(Photo: Pamela Littky/FOX)
In its first season, Best Medicine was FOX’s most-watched series of the 2025-26 TV season, outperforming 32 other shows. Will it continue to perform this well? Will the ratings grow or shrink in year two? Will Best Medicine be cancelled or renewed for season three? Stay tuned.
A medical comedy-drama series, the Best Medicine TV show is based on the UK’s long-running Doc Martin series. Josh Charles, Abigail Spencer, Josh Segarra, Cree, Stephen Spinella, Jason Veasey, and Annie Potts star. Recurring players include Carter Shimp, John DiMaggio, Clea Lewis, Didi Conn, Patch Darragh, Ben Lewis Doherty, Cindy De La Cruz, Gene Jones, and Jack Cutmore-Scott. In the story, Dr. Martin Best (Charles) is a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in Port Wenn, Maine, a quaint fishing village, where he spent summers as a child. Unfortunately, Martin’s blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, and he quickly alienates the town, even though he’s all they’ve got. Although Martin can expertly address any medical ailment or mystery in this idiosyncratic town, he’s really just desperate to be left the alone. Instead, he keeps getting dragged into the middle of their personal chaos, feuds and fantasies. What the locals don’t know is that Martin’s terse demeanor masks a debilitating new phobia and childhood trauma that prevent him from experiencing true intimacy with anyone. But tenacity is the creed of everyone in their small village, and the people who live there may be exactly what the doctor ordered.
